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奥美沙坦酯及其关键中间体的合成方法
Summary of synthesis methods of olmesartan medoxomil and key intermediates
【摘要】 奥美沙坦酯,一种血管紧张素Ⅱ1型受体(AT1)拮抗剂,用于高血压病的治疗。将该化合物的合成路线及其关键中间体——2-丙基-4-(1-羟基-1-甲基乙基)-1H-咪唑-5-羧酸乙酯和2-腈基-4’-甲基联苯(CMBP)的各种合成方法作一综合性论述。
【Abstract】 Olmesartan medoxomil,an angiotensinⅡ1 receptor(AT 1) antagonist,is widely used for the treatment of hypertension and related diseases.This review summarized the synthesis methods of olmesartan medoxomil and the key intermediates ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate and 2-cyano-4’-methyl-biphenyl(CMBP) thereof.Furthermore,each synthetic route was evaluated and compared with others.
- 【文献出处】 化学试剂 ,Chemical Reagents , 编辑部邮箱 ,2013年08期
- 【分类号】TQ463.5
- 【被引频次】8
- 【下载频次】800