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含二茂铁基的1,3,4-噻二唑化合物的合成及其生物活性研究
Synthesis and biological activity of 1,3,4-thiadiazole compounds containing ferrocenyl moiety
【摘要】 甲酰二茂铁与2-氨基-5-烷基/芳基-1,3,4-噻二唑在硅胶催化下反应,经硼氢化钾还原后得到18种新型2-二茂铁甲胺基-5-烷基/芳基-1,3,4-噻二唑。并通过IR、1HNMR和ESI/MS对其结构进行了表征。初步生物活性测试结果表明,部分化合物具有良好的生长调节活性。
【Abstract】 A series of novel N-(ferrocenyl-methyl)-5-alkyl/aryl-1,3,4-thiadiazol-2-amines were synthesized by the condensation of ferrocenecarboxaldehyde with 2-amino-5-alkyl/aryl-1,3,4-thiadiazoles in presence of silica gel and then reduction by potassium borohydride.All products were characterized by IR,1HNMR,and ESI/MS.Further,all synthesized compounds were screened for their auxin activity.Most of the compounds showed potent activity.
【关键词】 1,3,4-噻二唑;
二茂铁;
席夫碱;
生物活性;
【Key words】 1,3,4-thiadiazole; ferrocene; Schiff base; biological activity;
【Key words】 1,3,4-thiadiazole; ferrocene; Schiff base; biological activity;
- 【文献出处】 化学试剂 ,Chemical Reagents , 编辑部邮箱 ,2013年04期
- 【分类号】O627.81
- 【被引频次】9
- 【下载频次】210