【摘要】 目的观察辛伐他汀在脑血栓(CE)的临床疗效,以更好的指导脑血栓的临床用药。方法选取我院2007年5月-2011年4月收入院的84例脑血栓患者,随机分为研究组(42例)和对照组(42例)。两组患者都给予常规的卧床休息,调压,溶栓等治疗稳定病情,在此基础上,研究组予以口服辛伐他汀及阿司匹林治疗,对照组给予阿司匹林治疗,比较两组患者治疗前及治疗3、6、9个月后的颈动脉粥样硬化斑块内-中膜厚度(IMT),比较两组患者治疗前以及治疗9月后甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)的变化,综合以上指标判断辛伐他汀在脑血栓治疗中的临床疗效。结果研究组在6个月后IMT厚度减少,而对照组厚度增加;治疗9个月后,患者TC、LDL-C、TG均降低,HDL-C与治疗前及对照组比较,差异无统计学意义(P>0.05)。结论辛伐他汀不仅对延缓动脉粥样硬化有明显的疗效,还能降低血脂,不失为治疗脑血栓的一种良好药物,建议各医院推广使用。更多还原

【Abstract】 Objective Study on the clinical effect of simvastatin in the treatment of cerebral thrombosis to provide better guidance for the clinical medicine of cerebral thrombosis. Methods 84 patients with cerebral thrombosis treated in our hospital from May 2005 to April 3, 2008 are divided into simvastatin treatment group(42 cases) and control group(42 cases) randomly. Two groups of patients are given treatment of conventional bed rest, pressure regulation and thrombolysis and the like to stabilize the disease, patients in the treatment group are treated with oral simvastatin and aspirin on the above basis, while patients in the control group are treated with aspirin only. Compare the tunica media thickness(IMT) inside the atheromatous plaque before the treatment and 3, 6、9 after the treatment of the patients of two groups, compare the changes of TG、TC、HDL-C、LDL-C before the treatment and 9 months after the treatment of the patients of two groups, and determine the clinical effect of simvastatin in the treatment of cerebral thrombosis on the basis of the above indicators.Results the IMT thickness of patients in the treatment group decreases 6 months after the treatment, while that of patients in the control group increases(P<0.05); TC, LDL-C, TG of patients are reduced after been treated for 9 months, HDL-C is no big difference compared with that before the treatment(P>0.05). Conclusion Simvastatin not only has a significant effect on retarding atherosclerosis, but also reduces blood lipid, is a good drug for the treatment of cerebral thrombosis, and is recommended to be used in all hospitals.更多还原