【摘要】 目的:探讨湘西地区侗族人群2型糖尿病(type 2 diabetes mellitus,T2DM)的相关危险因素,为该地区T2DM的防治提供科学依据。方法:采用病例对照研究方法,通过口服葡萄糖耐量试验(oral glucose tolerance test,OGTT)将研究对象分为T2DM,糖调节受损(impaired glucose regulation,IGR)和糖耐量正常(normal glucose tolerance,NGT)3组,分别对3组人群进行问卷调查、体格测量以及血糖、血脂、血清胰岛素等生化指标检测。结果:单因素分析结果发现:不同糖代谢组间的年龄,空腹胰岛素(fasting insulin,FINS),HOMA模型胰岛素抵抗指数(HOMA insulin resistance index,HOMA-IRI)和β细胞功能指数(HOMAβ-cell function index,HOMA-βC),三酰甘油(trigalloyl glycerol,TG),高密度脂蛋白胆固醇(high density lipoprotein cholesferol,HDL-C),收缩压,舒张压等指标差异有统计学意义(P<0.05);体质量指数(body mass index,BMI)、腰臀比(waist/hip ratio,WHR)、糖尿病家族史、每周体力活动次数、吃饭口味、高脂高蛋白食物、新鲜蔬菜和水果摄入量与糖尿病有关。多因素非条件ordinal logistic回归分析发现:年龄是糖尿病的危险因素,与年龄≤50岁组相比,50岁<年龄≤60岁组,60岁<年龄≤70岁组和年龄>70岁组的OR值分别是1.85,2.83和2.64(P<0.05);BMI为超重或肥胖人群患糖尿病的风险是BMI正常人群的2.13倍(P<0.01);其他影响因素包括WHR(OR=2.06),糖尿病家族史(OR=11.36),高脂高蛋白食物(OR=1.90)。结论:湘西地区侗族人群T2DM的影响因素主要有年龄、BMI、WHR、糖尿病家族史、高脂高蛋白食物,提示今后应加强湘西地区侗族人群T2DM的健康教育,降低患T2DM的风险。更多还原

【Abstract】 Objective: To explore the risk factors of type 2 diabetes mellitus(T2DM) of Dong nationality in Western Hunan, and to provide a scienti c basis for the prevention and treatment of T2DM in the district. Methods: In the case-control study, the subjects were divided into a T2DM group, an impaired glucose regulation(IGR) group and a normal glucose tolerance(NGT) group through oral glucose tolerance test(OG). A questionnaire survey was conducted, and physical measurements and the detection of blood glucose, blood lipids and serum insulin were done. Results: Univariate analysis found significant difference in age, fasting insulin(FINS), HOMA insulin resistance index(HOMA-IRI), HOMA β-cell function index(HOMA-βC), trigalloyl glycerol(TG), high density lipoprotein cholesterol(HDL-C), systolic blood pressure, and diastolic blood pressure in the glucose metabolism among different groups(P<0.05). Body mass index(BMI), waist/hip ratio(WHR), family history of diabetes, number of physical activities per week, dinner taste, fat and protein-rich foods, fresh vegetables and fruits intake were associated with T2DM. Multifactor non-conditional ordinal logistic regression indicated that age was the risk factor of T2DM and IGR. Compared with the group whose age was≤50, the odds ratios of the groups of 50<age≤60, 60<age≤70 and age>70 were 1.85, 2.83 and 2.64 respectively, P<0.05. e risk of su ering from diabetes of the overweighted or obese people was 2.13 times that of a normal BMI group, P<0.01. The other influencing factors included WHR(OR=2.06), family history of diabetes(OR=11.36), and fat and protein-rich foods(OR=1.90). Conclusion: e main in uencing factors of T2DM of Dong nationality in Western Hunan include age, BMI, WHR, family history of diabetes, fat and protein-rich foods. We must strengthen the health eduation of T2DM of Dong nationality in Western Hunan to reduce the risk of T2DM.更多还原