【摘要】 目的观察丁苯酞软胶囊(NBP)治疗急性脑梗死的临床疗效和对血清神经元特异性烯醇化酶(NSE)、S-100B蛋白的影响。方法将收治的80例急性脑梗死病人随机分为对照组和治疗组,各40例。对照组给予银杏叶提取物注射液20mL静滴,1次/d;阿司匹林100mg口服,1次/d,疗程2周。治疗组在对照组的基础上给予NBP 200mg/次口服,3次/d,疗程2周。分别于治疗前、治疗后3d、7d、14d进行神经功能缺损评分及血清NSE、S-100B蛋白含量的测定。结果与对照组比较,治疗组在治疗后7d、14d神经功能缺损评分较对照组降低(P<0.01),治疗后3d、7d、14d血清NSE、S-100B蛋白含量明显下降(P<0.05)。结论丁苯酞软胶囊可以保护神经细胞,改善急性脑梗死病人的神经功能。更多还原

【Abstract】 Objective To observe the clinical effects of butylphthalide soft capsules(NBP) and its influence on the serum contents of neuron-specific enolase(NSE) and S-100B protein of patients with acute cerebral infarction.Methods Totally 80 patients were randomly divided into control group and treatment group(40 cases in each group).Forty patients in control group were treated with extract of Ginkgo Biloba leaves injection 20 mL,iv gtt,qd,and aspirin 100 mg,po,qd,while the treatment group was given NBP 200 mg,po,tid,and individually the former basic treatment,with a course of 14 days for each group.The nerve function deficiency scores and the serum contents of NSE and S-100B protein were observed before and after treatment for 3 days,7 days and 14 days.Results The nerve function deficiency scores of treatment group were lower than those of control group after 7 days and 14 days of treatment(all P<0.01).The serum contents of NSE and S-100B protein were significantly lower than those of control group after 7 days and 14 days of treatment(all P<0.05).Conclusion Butylphthalide soft capsules can protect nerve cells and improve neurological function in patients with acute cerebral infarction.更多还原