Objective To observe the efficacy and safety of high dose of esomeprazole in the treatment of acute nonvariceal upper gastrointestinal bleeding.Methods 74 cases of acute nonvariceal upper gastrointestinal bleeding were randomly divided into 2 groups,38 cases in the treatment group,which was treated with the first agent of 80mg esomeprazole intravenous injection,and then with continuous infusion at the speed of 8mg/h.36 cases in the control group were treated with 40mg esomeprazole intravenous drip,once ever...