【摘要】 目的:观察松花粉预防和延缓腮腺组织衰老IGF-I在腮腺导管细胞中的表达。方法:D-半乳糖连续腹腔注射制作亚急性衰老雄性大鼠模型,采用免疫组织化学方法(SP法)观察不同剂量的松花粉对衰老的腮腺组织IGF-I表达的影响。结果:IGF-I在腮腺组织广泛表达,D-半乳糖所致亚急性衰老大鼠模型组IGF-1的表达明显下降,与正常对照组比较差异显著(P<0.01);而经松花粉给药后IGF-I的表达明显上升,其中预防中剂量组效果明显。结论:松花粉具有改善衰老雄性大鼠腮腺功能紊乱,预防和延缓腮腺组织衰老的作用。更多还原

【Abstract】 Objective: To observe the expression of IGF-I during pollen pini preventing and delaying parotid tissues from getting senescent.Method: Made rat models with subacute senility by means of continuous intraperitoneal injection with D-galactosum and observed the effects of pollen pini of different on the expression of epidermal growth factor receptor(IGF-I) in senescent parotid tissues.Results: IGF-I was expressed extensively in parotid tissues,with the expression of IGF-I in the rat model group with subacute senility caused by D-galactosum fallen remarkably and shown a remarkable difference compared with the normal control group(P < 0.01);but after pollen pini was given into the senescent parotid tissues,the expression of IGF-I especially that in the medium did group,rose remarkably.Conclusion: Pollen pini had the effect of relieving the disorder of parotid tissues in senescent male rats and preventing and delaying their parotid tissues from getting senescent.更多还原