【摘要】 采用改进方法,苯乙酮与丙烯酸甲酯缩合制得4-苯甲酰基-1,7-庚二酸二甲酯,其结构经1H NMR和MS确证。较适宜的反应条件为:苯乙酮50 mmol,n(丙烯酸甲酯)∶n(苯乙酮)=2.5∶1.0,无水环境下,以甲醇钠为催化剂,于50℃反应24 h,收率12.8%。更多还原

【Abstract】 4-Benzoyl-heptanedioic acid dimethyl ester was prepared by condensation of acetophenone with methyl acrylate by improve method.The structure was confirmed by 1H NMR and MS.The optimal reaction conditions at 50 ℃ for 24 h were as follows: acetophenone was 50 mmol,n(methyl acrylate) ∶ n(acetophenone) was 2.5 ∶ 1.0,catalyst was MeONa in water-free.The yield was 12.8% under the optimal conditions.更多还原