【摘要】 采用溶剂辅助研磨法制备了阿折地平-马来酸复合物,应用XRD,DSC,IR,Raman,THz,ssNMR等手段对复合物进行表征,以探讨阿折地平与马来酸之间作用力的类型;采用溶解度方法推导和计算了二者在溶液中形成的热力学公式和参数;采用高效液相(HPLC)法测定了阿折地平的含量.在苯辅助研磨的条件下,阿折地平与马来酸以2∶1的物质的量比形成了新的复合物.热力学分析表明二者结合的强度较高,结合常数达105数量级.更多还原

【Abstract】 The complex built upon azelnidipine and maleic acid was synthesized by using solvent-assisted grinding method and was characterized by powder X-ray diffraction(PXRD),differential scanning calorimetry(DSC),infrared(IR) and Raman spectrum,solid-state nuclear magnetic resonance(ssNMR),and terahertz(THz) spectroscopy.The formation thermodynamics of the azelnidipine-maleic acid complex were extensively investigated by solubility method.The concentrations of azelnidipine were determined by HLPC method.New azelnidipine-maleic acid complex was formed at a molar ratio of 2∶1 by toluene-assisted cogrinding.The interactions between azelnidipine and maleic acid were discussed.Thermodynamics analysis indicated that the complex force between them was intense;the complex constants K were evaluated to be 105 orders of magnitude.更多还原