【摘要】 目的观察使用碳酸氢钠(NaHCO3)碱化血液对急性有机磷农药中毒(AOPP)的治疗作用。方法选择2007年1月—2009年12月在我院急诊科确诊并住院的43例AOPP,随机分为治疗组20例和对照组23例,治疗组常规治疗结合使用高剂量的NaHCO3(初始剂量1~2 h输注4 mmol/kg,随后5 mmol/(kg·d)直至康复或死亡,使动脉血pH值在7.40~7.50。对照组常规治疗结合等量生理盐水。结果两组无死亡病例,治疗24 h治疗组动脉血pH值较对照组显著增高(P<0.01),使用长托宁的总剂量显著低于对照组(P=0.011),住院时间显著短于对照组(P=0.012)。结论高剂量的NaHCO3治疗有益于AOPP中毒患者。更多还原

【Abstract】 Objective To observe the effect of blood alkalinization by using sodium bicarbonate( NaHCO3) in treatment of acute organophosphorus pesticide( AOPP). Methods A total of 43 patients with AOPP in our hospital during January 2007 and December 2009 were randomly divided into treatment group( n = 20) and control group( n = 23).Based on routine treatment,patients in treatment group were given higher doses of NaHCO3by infusion with 4 mmol /kg of initial dose at 1-2 hours,then followed by 5 mmol /( kg·d) until recovery or death,which maintained 7. 40-7. 50 of arterial pH value. Patients in control group accepted routine treatment combined with equivalent normal saline. Results Patients were all survived. Arterial pH value after treatment for 24 h in treatment group was significantly higher than that in control group( P < 0. 01). The accumulated dose of Penehyclidine Hydrochloride injection in treatment group was significantly lower than that in control group( P = 0. 011),and length of stay was shortened compared with that in control group( P = 0. 012). Conclusion High dose of NaHCO3in treatment of patients with AOPP is helpful.更多还原