【摘要】 目的分析海南地区淋巴组织增生性病变的病理分型及其与EB病毒感染的关系。方法收集我院最近5年淋巴组织增生性病变共524例,并对其中有完整资料的214例病例应用EB病毒编码小RNA(EBER)原位杂交检测淋巴组织中EB病毒(EBV)感染情况,分析EBV与不同类型淋巴瘤和淋巴结反应性增生的关系。结果 157例淋巴瘤进行了EBER检测,共有40例EB病毒(EBV)阳性,阳性率为25.48%,199例淋巴结反应性增生病变中,57例进行了EBER原位杂交检测,其中仅3例与EBV感染有关,阳性率为5.26%。结论 EBV与淋巴瘤,特别是T细胞淋巴瘤的发生有一定关系,以副皮质区增生为主的淋巴结反应性增生可能与EBV感染有关。更多还原

【Abstract】 Objective To explore the relationship between Epstein-Barr virus(EBV) infection and the patho- logic classification of lymphoproliferative disorders in Hainan. Methods In situ hybridization(ISH) for EBV-encod- ed small RNA(EBER) was performed to detect the infection of EBV in 214 patients, selected from 524 patients with lymphoproliferative disorders in our hospital in the recent 5 years. The relationship between EBV infection and the pathologic classification of lymphoproliferative disorders was analyzed. Results The positive cases of EBER in lym- phoma(157 cases) was 40, with the positive rate of 25.48%, including 4(3.96%) in 101 cases of B-cell non-Hodgkin lymphoma(B-NHL), 27(61.36%) in 44 cases of T-cell non-Hodgkin lymphoma(T-NHL), and 9(75%) in 12 cases of classical Hodgkin lymphoma mixed cellularity(CHL-MC). The positive cases of EBER in lymph node reactive hyper- plasia(57 of the 199 cases tested) was 3, with the positive rate of 5.26%. Conclusion There is a correlation between EBV infection and Lymphoma, especially T-cell lymphoma, and also between EBV infection and lymph node reactive hyperplasia更多还原