【摘要】 目的探讨甲状腺瘤、结节性甲状腺肿及甲状腺功能亢进患者凝血功能状态及其与甲状腺功能的相关性。方法收集33例甲状腺瘤、46例结节性甲状腺肿和34例甲亢患者的枸橼酸钠抗凝全血及血清标本,Sysmex CA-7000型全自动凝血分析仪检测患者血浆凝血酶时间(PT)、活化部分凝血时间(APTT)和纤维蛋白原(Fib)水平;雅培i2000化学发光仪检测血清促甲状腺激素(TSH)、游离甲状腺素(FT4)和游离三碘甲腺原氨酸(FT3)含量。以44例健康体检者作为对照组,比较甲状腺疾病患者与正常对照组凝血功能差异,并分析甲状腺疾病患者凝血功能与甲状腺功能的相关性。结果甲状腺瘤、结节性甲状腺肿及甲亢患者PT、APTT水平均显著低于正常对照组;结节性甲状腺肿和甲亢患者Fib水平显著高于对照组,甲状腺瘤患者Fib水平升高不明显;甲状腺瘤、结节性甲状腺肿、甲亢患者的PT、APTT、Fib水平与TSH、FT4、FT3水平无相关性。结论甲状腺疾病患者存在凝血功能的紊乱,有形成血栓的潜在危险。更多还原

【Abstract】 Objective To investigate the coagulation function of patients with thyroid adenoma, nodular goiter and hyperthyroidism, and to analyze the relationship between coagulation function and thyroid hormones.Methods Both blood samples anti-coagulated with sodium citrate and serum was collected from 33 patients with thyroid adenoma, 46 patients with nodular goiter and 34 patients with hyperthyroidism. Sysmex CA-7000 automatic blood coagulation function analyzer was used to measure prothrombin time(PT), activated partial thromboplastin time(APTT) and fibrinogen(Fib). Thyroid stimulating hormone(TSH), free-T4(FT4) and free-T3(FT3) was tested by the Abbott i2000 chemiluminescence analyzer. Forty-four healthy people with normal thyroid hormones were collected as the control group. Then we compared the coagulation function of patients with thyroid diseases with that of healthy people.And the relationship between coagulation function and thyroid hormones were analyzed. Results Compared with the control group, the levels of PT, APTT in patients with thyroid adenoma, nodular goiter and hyperthyroidism were significantly lower, and the levels of Fib in patients with nodular goiter and hyperthyroidism were significantly higher. The increase of Fib in patients with thyroid adenoma was not significant. There was no correlation between the levels of PT, APTT, Fib and TSH, FT4, FT3in patients with thyroid adenoma, nodular goiter and hyperthyroidism. Conclusion Patients with thyroid diseases have blood coagulation dysfunction and are more likely to cause thrombosis.更多还原