【摘要】 目的探讨不同剂量地佐辛复合依托咪酯应用于无痛胃镜检查的麻醉效果。方法 90例行无痛胃镜检查的患者,随机分为三组,每组30例:地佐辛15μg/kg复合依托咪酯麻醉组(Ⅰ组),地佐辛30μg/kg复合依托咪酯麻醉组(Ⅱ组)和单纯使用依托咪酯麻醉对照组(Ⅲ组)。记录用药前(T0)、检查开始(T1)、检查结束(T2)的MAP、HR、RR、SpO2,苏醒时间及依托咪酯用量;观察不良反应。结果三组患者各时点的MAP、HR、R、SpO2比较差异无统计学意义(P>0.05);Ⅱ组依托咪酯用量较Ⅰ组、Ⅲ组少(P<0.05);三组苏醒时间比较差异无统计学意义(P>0.05)。Ⅰ组、Ⅱ组恶心呕吐、注射痛、肌阵挛及呼吸抑制等不良反应发生率低。结论3 0μg/kg地佐辛复合依托咪酯在无痛胃镜检查中应用,血流动力学波动小,苏醒迅速,依托咪酯的用量减少和减少肌阵挛的发生。更多还原

【Abstract】 Objective To explore the anesthetic efficacy of different doses of dezocine combined with etomidate in painless gastroscopy. Methods Ninety ASA Ⅰ～Ⅱ patients scheduled for painless gastroscopy were randomly divided into three groups: group Ⅰ (n=30, applying 15 μg/kg dezocine combined with etomidate for anesthesia), group Ⅱ(n=30, 30 μg/kg dezocine combined with etomidate for anesthesia ), group Ⅲ (n=30, applying etomidate alone). MAP, HR, RR and SpO2were measured before anesthesia (T0), at the beginning of examination (T1), at the end of examination (T2). The doss of etomidate, awake time of patients and the adverse reaction were recorded. Results MAP, HR, R, SpO2, at T0, T1, T2 had no statistically significant differences between the three groups (P>0.05). Compared with group Ⅰ and group Ⅲ, the doses of etomidate in group Ⅱ was significantly lower (P<0.05). The awake time showed no statistically significant differences between the three groups (P>0.05). Compared with group Ⅲ, the adverse reaction such as nausea, vomiting, injection pain, myoclonus and respiratory depression in group Ⅰ and group Ⅱ were significantly lower. Conclusion Anesthesia using 30 μg/kg dezocine combined with etomidate in painless gastroscopy can steady bloodstream dynamics, promote analepsia, and reduce the dosage of etomidate and myoclonus.更多还原