【摘要】 目的研究转化生长因子β1(TGF-β1)基因-509C/T、+869T/C多态性与大肠腺瘤的相关性。方法采用聚合酶链反应-限制性片段长度多态性方法,检测82例大肠腺瘤患者以及102例正常对照者TGF-β1基因-509C/T、+869T/C多态性,并分析该基因多态性与大肠腺瘤临床病理特征之间的关系。结果 TGF-β1-509C/T、+869T/C等位基因频率及基因型频率在大肠腺瘤组和对照组的总体分布差异无统计学意义。将大肠腺瘤患者按性别分组后,大肠腺瘤女性患者与男性比较,-509TT基因型频率有增高趋势(30.3%vs14.3%,P=0.079,OR=2.609,95%CI:0.876~7.771),但差异无统计学意义。结论 TGF-β1-509C/T多态性及+869T/C多态性与大肠腺瘤易感性无关。更多还原

【Abstract】 Objective To determine the association of the -509C/T, +869T/C polymorphism of transforming growth factor beta 1 (TGF-β1) gene with the risk of colorectal adenoma. Methods TGF-β1gene polymorphism for 82 patients with colorectal adenoma (the study group) and 102 healthy controls (the control group) were detected by polymerase chain reaction (PCR) and restriction analysis. Association of the genotype and allele frequencies was stud- ied with the clinical and pathological features of colorectal adenoma. Results No significant difference was found in genotype and allele frequency distributions between the study group and the control group. The TT genotype was slightly higher in female adenoma patients than male adenoma patients (30.3% vs 14.3%, P=0.079, OR=2.609, 95% CI: 0.876～7.771), but the difference was not significant. Conclusion TGF-β1-509C/T and +869T/C polymorphism is not associated with colorectal adenoma.更多还原