【摘要】 目的了解住院患者中革兰氏阳性球菌的分布及其对常用抗菌药物的耐药状况,为临床预防和控制住院患者革兰氏阳性球菌感染提供参考。方法对四川省人民医院2011年临床分离的1927株革兰氏阳性球菌采用Vitek全自动细菌鉴定仪及纸片扩散法(K-B法)进行细菌鉴定及药物敏感性分析。结果 1927株革兰氏阳性球菌中,以金黄色葡萄球菌为主,占42.35%,其次为表皮葡萄球菌,占28.75%,屎肠球菌、肺炎链球菌、溶血葡萄球菌、粪肠球菌分别占12.51%、5.55%、5.45%及5.40%。金黄色葡萄球菌中耐甲氧西林金黄色葡萄球菌检出率占66.85%。所有葡萄球菌对利奈唑胺及替加环素均敏感,金黄色葡萄球菌对万古霉素的敏感性为99.63%;粪肠球菌对万古霉素及替加环素均敏感,对利奈唑胺不同程度耐药;屎肠球菌对利奈唑胺、万古霉素及替加环素均有不同程度耐药;肺炎链球菌对万古霉素及替加环素均敏感。结论葡萄球菌、肠球菌及肺炎链球菌耐药性需加强监测,并采取有效控制措施。更多还原

【Abstract】 Objective To investigate the distribution of Gram-positive coccus in inpatients and the drug in Gram-positive coccus, in order to provide reference for managing Gram-positive Cocci infection. Methods A total of 1 927 strains of Gram-positive Cocci isolated in Sichuan Provincial People’s Hospital were identified with a Vitek 2 microbiology analyzer. Antimicrobial susceptibility testing was performed by First-Bauer disk diffusion. Results Of the 1 927 strains, Staphylococcus aureus accounted for 42.35%, followed by staphylococcus epidermidis (28.75%), Enterococcus faecium (12.51%), Streptococcus pneumoniato (5.55%), staphylococcus hemolyticus (5.45%) and Enterococcus faecalis (5.40%). Methicillin-resistant strains in Staphylococcus aureus accounted for 66.85%. All the Staphylococcus strains were found sensitive to linezolid and tigecycline. The sensitivity rate of Staphylococcus aureus to vancomycin was 99. 63%. Enterococcus faecalis was sensitive to vancomycin and tigecycline, but showed resistance to linezolid. Enterococcus faecalis was also found to be resistant to linezolid, vancomycin and tigecycline. Streptococcus pneumoniato was found sensitive to linezolid and tigecycline. Conclusion Surveillance of drug resistance of Staphylococcus, Enterococcus and Streptococcus pneumoniato is very important, and effective control measures are necessary.更多还原