【摘要】 目的:探讨肺部手术围手术期氨溴索的合适剂量。方法:选择在深圳市第二人民医院实施肺部手术的295例患者作为研究对象,分为对照组和A、B、C、D治疗组,每组各59例。A、B、C、D组术后分别使用30、60、90、120 mg盐酸氨溴索,对照组使用生理盐水100 mL。比较各组术后排痰情况、并发症发生率及抗生素使用时间。结果:治疗组治愈率、好转率高于对照组(P<0.05);C、D组治愈率、好转率均高于A、B组(P<0.05)。对照组并发症发生率高于治疗;A、B组并发症发生率高于C、D组(P<0.05)。对照组抗生素使用时间长于治疗组(P<0.05),A、B、C组抗生素使用时间长于D组(P<0.05)。结论:氨溴索可有效防止肺部手术围手术期的呼吸系统并发症,其临床剂量使用应适当偏用高剂量,具体最适剂量仍待进一步探索。更多还原

【Abstract】 Objective:To investigate the appropriate perioperative dosing scheme for ambroxol in patients scheduled for lung surgery.Methods:We randomly allocated 295 patients who were scheduled for lung surgeries in Shenzhen Second People’s Hospital to be treated with 100 mL natural saline intravenous injection(control group,n = 59),30 mg ambroxol thrice daily(group A,n = 59),60 mg ambroxol thrice daily(group B,n =59),90 mg ambroxol thrice daily(group C,n =59) and 120 mg ambroxol thrice daily(group D,n =59),respectively.We next compared the volume of sputum expectorated,the incidence of respiratory complications and the use of antibiotics.Results:Compared with control group,all treatment groups yielded a significantly higher rates of recovery and remission yet a lower incidence rate of complications(all P < 0.05).This held true for the comparisons between groups C and D,and between groups A and B(both P < 0.05).The control group was associated with a prolonged period of antibiotic use(all P <0.05).Compared with groups A,B and C,a longer period of antibiotic use was noted in group D(all P < 0.05).Conclusions:Ambroxol effectively prevents from the incidence of perioperative respiratory complications.Despite that relatively high doses of ambroxol are recommended for clinical application,the optical doses merits further studies.更多还原