【摘要】 介绍一种合成环丙羧酸的新工艺。以固体光气为原料,与2,4-二氯氟苯反应制得2,4-二氯-5-氟苯甲酰氯,然后与3-乙氧基丙烯酸乙酯偶联,后经环丙胺置换、在DMF中环合、水解制得环丙羧酸,总收率为39.1%。该工艺流程缩短、操作简单,环境污染小,值得进一步研究和推广。更多还原

【Abstract】 New process for preparing cycloprophyl carboxylic acid was described.The target was prepared from 2,4 Dichloro-1-fluorobenzene,which reacted with ethyl 3-ethoxyacrylate,amination with cyclopropylamine,cyclization under DMF and hydrolysis.The total yield was 39.1%.The process had many advantages,such as simple operation and less environmental pollution.In line with the green chemistry development direction,it deserved further research and popularization.更多还原