【摘要】 目的了解HIV/AIDS患者中分枝杆菌感染情况。方法对291例HIV/AIDS患者痰分枝杆菌培养阳性结果进行菌种鉴定:结核分枝杆菌(MTB)采用MTB PCR mix进行扩增鉴定,非结核分枝杆菌(NTM)采用16SrRNA基因测序法进行鉴定。结果 291例HIV/AIDS患者痰分枝杆菌培养阳性,其中MTB感染156例占53.61%,NTM感染135例占46.39%。NTM鉴定有15种,其中鸟分枝杆菌复合群最多占58.52%。291例患者中男性分枝杆菌感染比例为79.73%,高于女性的20.27%(P<0.05)。不同性别、年龄组结核分枝杆菌感染率比较,差异无统计学意义(P>0.05)。结论 HIV/AIDS患者痰培养分枝杆菌阳性中NTM占的比例较高。由于感染NTM的治疗方案不同,对于HIV/AIDS患者的临床诊断和治疗应重视分枝杆菌培养鉴定结果。更多还原

【Abstract】 Objective To explore the situation of mycobacterium infections in patients with HIV/AIDS.Methods Species identification of 291 sputum cultures positive in patients with HIV/AIDS was performed in the study.MTB PCR mix was used for species identification of mycobacterium tuberculosis(MTB),and 16SrRNA gene sequencing for nontuberculous mycobacterium(NTM).Results 291 sputum were cultured positive in patients with HIV/AIDS,in which 156 cases were MTB(53.61%) and 135 cases were NTM(46.39%).Fifteen NTM were identified,in which mycobacterium avium-intracellulare tuberculosis complex accounted for 58.52%(the most).In 291 patients with mycobacterium infections,the male accounted for 79.73%,more than the female(20.27%,P<0.05).There was no significant difference in mycobacterium infection among patients with different gender and different age(P>0.05).Conclusion NTM takes up a high proportion in mycobacterium culture positive in patients with HIV/AIDS.Species identification of mycobacterium should be valued in the diagnosis and treatment of HIV/AIDS for different schemes of NTM infections.更多还原