【摘要】 目的探讨白癜风患者治疗前后血清SOD、M-CSF和MMP-2水平的变化以及临床上的意义。方法采用酶联法和放射性免疫分析法对36例白癜风患者进行了治疗前后体内血清SOD、M-CSF和MMP-2水平检验测试,并同32例健康人做比较。结果白癜风患者与健康人组相比较,治疗前血清SOD水平显著低于健康人组(P<0.01),血清M-CSF和MMP-2水平相比较,治疗组显著高于健康人组(P<0.01)。患者经过为期6个月治疗后体内血清SOD、M-CSF和MMP-2水平与正常人相比较仍存差异在统计学意义(P<0.05)。结论白癜风患者自身免疫调节系统功能较差,免疫调节异常,患者体内血清SOD、M-CSF、MMP-2水平的变化是衡量治疗后预后和临床观察的重要指标。更多还原

【Abstract】 Objective To explore the effects of vitiligo patients before and after treatment serum SOD,the M-CSF and MMP-2 levels of changes and clinical significance. Methods Used ELISA and radioimmunoassay to test the level of serum SOD, M-CSF and MMP-2 before and after treatment for 36 cases with vitiligo.and compared with 32 healthy people. Results The serum SOD levels of patients with vitiligo were significantly lower than healthy people group before treatment(P < 0.01),and M-CSF and serum level of MMP-2 in comparison, the treatment group was significantly higher than healthy group(P < 0.01),After 6 months treatment in patients with serum SOD,the M-CSF and MMP-2 levels compared with normal people there was still a significant difference(P < 0.05). Conclusion Immune regulating system function in patients with vitiligo is poorer,immune dysregulation in patients,patients’ serum SOD in the body, the M-CSF,changes in the level of MMP-2 is the important indicators of prognosis after treatment and clinical observation.更多还原