【摘要】 目的探讨不同剂量丹参酮ⅡA磺酸钠及其与丹参治疗乙肝肝衰竭疗效。方法乙肝肝衰竭患者,随机分为对照组、低剂量组、中剂量组、高剂量组四组,每组30例。均给予基础治疗并分别给予丹参及低、中、高剂量丹参酮ⅡA磺酸钠,监测治疗前及治疗2、4周的ALT、TB值。结果同组中,随治疗周期延续,ALT、TB明显下降(P<0.01);治疗4周中剂量组及高剂量组分别与对照组比较ALT明显下降(P<0.05);治疗4周中剂量组ALT与低剂量组比较ALT明显下降(P<0.01);治疗4周中剂量组ALT与高剂量组比较ALT明显下降(P<0.01)。治疗2或4周中剂量组及高剂量组分别与对照组比较TB明显下降(P<0.01或0.05);治疗2周中剂量组TB与低剂量组比较TB明显下降(P<0.05);治疗4周中剂量组及高剂量组分别与低剂量组比较TB明显下降(P<0.01或0.05)。结论丹参酮ⅡA磺酸钠治疗乙肝肝衰竭疗效优于丹参;丹参酮ⅡA磺酸钠治疗乙肝肝衰竭时应选择适当的剂量。更多还原

【Abstract】 Objective To study therapeutic effects between the different dosage Sulfotanshinone Sodium and Salvia miltiorrhiza in treating hepatic failure with hepatitis B. Methods Patients of hepatic failure with hepatitis B were divided into four groups(control group,low dosage group,middle dosage group,high dosage group)randomly,thirty Patients per group, who were given basic therapy as well as Salvia miltiorrhiza and the low、middle or high dosage Sulfotanshinone Sodium respectively, The ALT and TB values of pretreatment and 2,4weeks’ treatment were measured. Results As to the same group,the ALT and TB values were significantly decreased by the extension of treatment cycles(P < 0.01),the ALT values of the middle and high dosage groups were significantly decreased than those of control group after 4 weeks treatments(P < 0.05).The ALT values of the middle dosage group were significantly decreased than those of the the low dosage group after 4 weeks treatments(P < 0.01),the ALT values of the middle dosage group were significantly decreased than those of the high dosage group after 4 weeks treatments(P < 0.01),The TB values of the middle and high dosage groups were significantly decreased than those of the control group after 2 or 4 weeks treatments(P < 0.01 or 0.05),The TB values of the middle dosage group were significantly decreased than those of the low dosage group after 2 weeks treatments(P < 0.05),the TB values of the middle and high dosage groups were significantly decreased than those of the low dosage group after 4 weeks treatments(P < 0.01 or 0.05).Conclusion Sulfotanshinone Sodium has better efficacy than that of Salvia miltiorrhiza in treating hepatic failure with hepatitis B.Adequate dosage of Sulfotanshinone Sodium in treating hepatic failure with hepatitis B would be selected.更多还原