【摘要】 脂肪酸结合蛋白3(fatty acid binding protein 3,FABP3)是脂肪酸结合蛋白家族成员之一,广泛存在于心肌、骨骼肌和泌乳期乳腺等对脂肪酸有高度需求的组织中。它参与胞内脂肪酸的短暂存储和运输,使脂肪酸进入线粒体能量代谢体系,氧化分解并产生ATP,为组织提供能量。它与脂肪酸结合形成胞内外浓度差,促进细胞摄取脂肪酸。作者主要介绍了FABP3基因及蛋白质结构、生物学功能和临床应用,并对其在乳脂合成信号转导通路中的研究进展进行了综述。更多还原

【Abstract】 Fatty acid binding protein 3(FABP3)is a member of the fatty acid binding protein family and widely present in the myocardium,skeletal muscle and lactating breast in which tissues fatty acids are highly in demand.It is involved in transient storage and transportation of intracellular fatty acids.Into the mitochondrial energy metabolism system,fatty acid is oxidized and decomposed and produces ATP and provides energy for organisms.It combines with fatty acids to form intracellular and extracellular concentration differences and promotes the cellular uptake of fatty acids.This paper mainly introduces gene and protein structure,biological function and clinical application of FABP3and reviews research progress of FABP3in the milk fat synthesis signal transduction pathway.更多还原