【摘要】 目的探讨血清降钙素原(PCT)和C反应蛋白(CRP)作为儿童血流感染(BSI)中血培养阳性预测指标的应用价值,为BSI的早期诊断和治疗提供依据。方法选取253例入院初期同时进行血培养和PCT、CRP检测的疑似血流感染患儿进行分析,其中血培养阳性组(BC阳性组)53例,随机选取的血培养阴性组(BC阴性组)200例。结果 BC阳性组中PCT、CRP水平均显著高于BC阴性组(PCT中位数分别为4.36、0.53ng/mL,P<0.01;CRP中位数分别为22.18、8.02mg/L,P<0.01)。ROC曲线显示,PCT作为血培养阳性的预测指标优于CRP(ROC曲线下面积PCT为0.802,CRP为0.544)。革兰阴性菌阳性标本中PCT水平(50.85ng/mL)显著高于革兰阳性菌阳性标本(2.16ng/mL),差异有统计学意义(P<0.05)。结论 PCT对儿童疑似血流感染的血培养送检标本中阳性标本的预测具有较高的敏感性和特异性,优于CRP。更多还原

【Abstract】 Objective To evaluate the application of procalcitonin(PCT)and C-reactive protein(CRP)in the prognosis of blood culture positive results among bloodstream infection children.Methods 253children with suspected bloodstream infections were enrolled in the study.PCT and CRP of all the children were detected.In a total of 253children,there were 53cases proved positive in bacterial culture(BC positive group),and other 200cases were proved negative(BC negative group).Results Both the levels of PCT and CRP of BC positive group were higher than those of BC negative group(PCT median 4.36ng/mL vs 0.53ng/mL,CRP median 22.18mg/L vs 8.02mg/L,P<0.01).ROC curves showed that PCT presented higher specificity for predetermined blood culture positive than CRP.Conclusion PCT as predictors of blood culture positive among children with bloodstream infection is more sensitive and specific than CRP,and it can provide reasonable basis for early diagnosis and drug use,especially in the emergency department.更多还原