【摘要】 目的探讨临床深部真菌感染检测指标的可行性并对其进行评价。方法通过分析深部真菌感染在医院中的分布,以及进行感染常见检测指标[如C-反应蛋白(CRP)、降钙素原(PCT)与(1-3)-β-D葡聚糖]的相关性分析,从而推测临床深部真菌感染的可靠检测指标。结果深部真菌感染在ICU、呼吸科、内分泌科、血液科、肿瘤科、儿科的送检率分别为59%、47%、33%、31%、24%、19%。患者体内(1-3)-β-D葡聚糖与CRP及PCT进行相关性分析,相关系数(r)分别为0.455、0.744(P=0.044,P=0.000)。菌群失调患者中,(1-3)-β-D葡聚糖检测的阳性率为16.7%,处于病变期的阳性率为53.3%。结论深部真菌感染在医院内以ICU、呼吸科、内分泌科、血液科、肿瘤科多见。PCT作为深部真菌感染的实验室检测指标比CRP更具可行性,PCT联合G试验对诊断临床深部真菌感染意义更大。更多还原

【Abstract】 Objective To investigate the feasibility of clinical detection index for deep fungal infection and its evaluation.Methods By analyzing the distribution of deep fungal infection in the hospital and the correlation of detection index for common infection(such as CRP and PCT)and(1-3)-beta-D glucan,thus speculated that clinical reliable detection index of deep fungal infection.Results The inspection rate of deep fungal infection in ICU and respiratory medicine,endocrinology,hematology,oncology,pediatrics was 59%,47%,33%,47%,24%and 19%,respectively.According to the correlation analysis of patient′s body(1-3)-beta-D glucan and CRP and PCT.The correlation coefficient r was 0.455,0.744,respectively.Pvalue was 0.044and 0.000,respectively.In patients with dysbacteriosis,G test positive rate was 16.7%and in lesions of the positive rate was 53.3%.Conclusion Deep fungal infection is common in ICU,respiratory,endocrinology,hematology and oncology in the hospital.Although CRP,PCT and(1-3)-β-D glucan are positively correlated,CRP is not intended to diagnose deep fungal infection.As a laboratory detection index of deep fungal infection,PCT is more feasible than CRP,PCT combined with G test for diagnosis of clinical deep fungal infection is more meaningful.更多还原