【摘要】 目的比较分析抗双链DNA(dsDNA)、抗Sm、抗核小体、抗组蛋白抗体联合检测对系统性红斑狼疮(SLE)的诊断意义。方法选取2012年6月至2013年3月间的83例SLE患者、65例非SLE自身免疫性疾病患者(包括肌炎、硬化症、类风湿关节炎)、70例健康体检者作为对照组,使用UNION免疫分析仪全自动定量检测系统分析这四种抗体。比较四者用于SLE诊断的灵敏度、特异度以及联合检测的结果。结果抗dsDNA抗体、抗Sm抗体、抗核小体抗体、抗组蛋白抗体对SLE诊断的灵敏度分别为75%、41%、67%、79%,特异度分别为89%、100%、98%、47%。四种指标联合检测的灵敏度和特异度分别为98%和100%。结论四种抗体对SLE都具有诊断价值。四种抗体联合检测能提高SLE的检出率,尤其通过使用UNION免疫分析仪进行四项套餐式定量检测,可以为患者提供快速、可靠的检测报告,在提高医院诊疗水平的同时为患者减少了就医成本。更多还原

【Abstract】 Objective To evaluate the significance of combined detection of anti-dsDNA , anti-Sm , anti-nuclesome , anti-histone in diagnosing systemic lupus erythematosus ( SLE ) .Methods 83patients with SLE , 65patients with other autoimmune disease , including myositis , sclerosis and rheumatoid arthritis , and 70people as the healthy control group from June 2012to March 2013were recruited in the study.UNION automatic quantitative analyzing system was adopted to test the anti-dsDNA , anti-Sm , anti-nuclesome and anti-histone.Sensitivity and specificity were compared among the 4indicators and the combined detection.Results The sensitivity of anti-dsDNA , anti-Sm , anti-nuclesome , anti-histone in the patients with SLE were 75% , 41% , 67% , 41% respectively , the specificity were 89% , 100% , 98%and 100%respectively.The sensitivity and specificity of the combined detection rose to 98%and 100%.Conclusion These 4kinds of antibodies have diagnostic value for SLE.Combined detection of the 4kinds of antibodies can improve the positive diagnostic rate of SLE , especially by UNION immunity analyzer for quantitative detection with 4package type which can provide fast and reliable test report for patients to improve the diagnosis of SLE while reduce the medical cost for patients.更多还原