【摘要】 目的了解该院临床科室金黄色葡萄球菌感染的分布特征及其耐药情况,为感染监控及临床合理用药提供依据。方法回顾性分析该院2012年1～12月临床科室金黄色葡萄球菌的感染分布及耐药率。结果 166株金黄色葡萄球菌在30个科室当中,分布在前6名的科室分别为呼吸科、手外科、急诊病房15株(各9.0%)、新生儿科14株(8.4%)、其次为肾内科及骨科13株(各7.8%),其中,耐甲氧西林金黄色葡萄球菌有103株,占62.0%;标本主要类型为分泌物,其次为痰液标本,分别为82株(49.4%)、62株(37.3%);金黄色葡萄球菌对常见12种药物耐药排前5位的分别是青霉素G(89.8%)、红霉素(50.6%)、四环素(38%)、头孢西丁(31.9%)及克林霉素(28.3%);敏感率最高的为万古霉素和利奈唑胺(各100.0%),其次为替考拉宁(99.4%)米诺环素(94.9%)。结论金黄色葡萄球菌表现出较高的多重耐药性及高耐药性,万古霉素、利奈唑胺、替考拉宁及米诺环素仍为有效控制金黄色葡萄球菌感染的最佳药物,但仍需结合药敏试验合理使用抗菌素。更多还原

【Abstract】 Objective To study the infectious distribution of Staphylococcus aureus(SA) isolated from Shenzhen People′s Hospital and its drug resistance to 12 kinds of common antibiotics;To guide clinical uses antibiotics reasonably.Methods Retrospective analysis of infection distribution and drug resistance of Staphylococcus aureus Hospital clinical departments from January to December 2012.Results 166 strains of Staphylococcus aureus in 30 departments,distribution in the top 6 departments respectively was department of respiration,surgery,emergency ward 15 strains(9% respectively),14 strains(8.4%) of neonatology,then renal internal medicine and orthopedics 13 strains(7.8% respectively).Among them,methicillin-resistant Staphylococcus aureus 103 strains was accounting for 62%;The main types of specimens of secretion 82 strains(49.4%),followed by sputum samples 62 strains(37.3%),respectively;12 kinds of common drug resistant Staphylococcus aureus in the top 5 were ranked penicillin G(89.8%),erythromycin(50.6%),tetracycline(38%),cefoxitin(31.9%)and clindamycin(28.3%);The sensitive rate to vancomycin and linezolid was highest(100% respectively),followed by teicoplanin(99.4%),minocycline(94.9%).Conclusion SA have high and multiple drug resistance to antimicrobial agents,especially for MRSA.Minocycline,Linezolid,Vancomycin,Teicoplanin are the first drug against SA infection,even MRSA.So great attention should be paid according to the antimicrobial susceptibility.更多还原