【摘要】 目的探讨脑梗死患者血清基质金属蛋白酶-9(MMP-9)及其抑制剂(TIMP-1)浓度的变化及与梗死面积的关系。方法收集90例脑梗死患者的血清,按梗死面积分成小、中、大3组,用酶联免疫吸附(ELISA)法测这90例患者第1、5、10天的MMP-9和TIMP-1浓度。同时检测30例健康体检者血清MMP-9和TIMP-1浓度。结果小、中、大3组之间MMP-9和TIMP-1的浓度差异均存在统计学意义(P<0.01),梗死面积越大,MMP-9和TIMP-1的浓度越高。MMP-9和TIMP-1的浓度在第1、5、10天均高于对照组(P<0.01)。结论 MMP-9和TIMP-1参与了脑梗死的发生和发展,测定MMP-9和TIMP-1水平对于脑梗死患者病情的判断和治疗具有重要的意义。更多还原

【Abstract】 Objective To study the cerebral infarction patients serum serum matrix metalloproteinase-9(MMP-9) and its inhibitor(TIMP-1) concentration of change and the relationship between the area of infarction.Methods the data of 90 cases of cerebral infarction patients serum,according to the infarction area divided into small,middle and junior group,90 patients day 1,5 and 10 days of MMP-9 and TIMP-1 concentration was detected by ELISA.At the same time testing the healthy check-up 30 patients serum MMP-9 and TIMP-1 concentration.Results small,medium and junior group between MMP-9 and TIMP-1 concentration difference there were statistical significance(P<0.01),infarction area is larger,MMP-9 and TIMP-1 the higher concentration.MMP-9 and TIMP-1 in the concentration of 1,5,10 days are higher than the control group(P<0.01).Conclusion The MMP-9 and TIMP-1 involve in the occurrence and development of cerebral infarction,it is of great significance that the cerebral infarction patients are judged the illness and treatment accoding the level of MMP-9 and TIMP-1.更多还原