【摘要】 目的分析脑膜炎败血黄杆菌所致ICU患者医院获得性感染的临床特征及其耐药性。方法根据是否发生脑膜炎败血黄杆菌所致医院获得性感染将ICU患者分为观察组和对照组,分析感染的危险因素并进行菌株鉴定和药敏实验。结果年龄不小于55岁、有糖尿病、有恶性肿瘤、使用抗菌药物及接受有创操作是导致疾病发生的危险因素,病原菌对哌拉西林/他巴唑坦、头孢哌酮/舒巴坦、替卡西林/克拉维酸、复方新诺明、环丙沙星的耐药率分别为16.85%、19.1%、46.07%、60.67%、38.20%,对其他抗菌药物的耐药率均高于95%。结论脑膜炎败血黄杆菌具对多种抗菌药物具有耐药性,应选择敏感性较高的哌拉西林/他巴唑坦、头孢哌酮/舒巴坦。更多还原

【Abstract】 Objective To explore the clinical feature of hospital acquired infection(HAI) caused by Flavobacterium meningosepticum in patients of ICU and analyze the drug resistance.Methods Patients of ICU were divided into observation group and control group according to with or without HAI caused by Flavobacterium meningosepticum. The risk factors for infection were analyzed and strain identification and drug sensitive test were performed.Results At least 55 years old, diabetic, malignant tumor, using of antibiotics and invasive operation were risk factors of this infection disease. The drug resistance rates of pathogenic bacteria to piperacillin/methimazole, cefoperazone/sulbactam, ticarcillin/clavulanate, cotrimoxazole and ciprofloxacin were 16.85%, 19.1%,46.07%,60.67% and 38.20%,and those to other antibacterials were all above 95%. Conclusion Flavobacterium meningosepticum might be resistant to multiple antibacterials, and piperacillin/methimazole and cefoperazone/sulbactam should be the first choice for clinical therapy.更多还原