【摘要】 细胞失巢凋亡是由于细胞与细胞外基质分离而引起的通过传统凋亡途径实现的凋亡。整联蛋白(INT)是细胞表面的一类糖蛋白受体,兼具黏附和信号传导功能,参与调节细胞的生存、增殖、黏附和分化过程。本文就INT的结构和功能,INT与失巢凋亡等研究进展作一综述。更多还原

【Abstract】 Anoikis is defined as a special form of programmed cell death,which is induced by inadequate or inappropriate cell-matrix interactions.Integrins sense and conduct cell-matrix signals,thus controlling the survival,proliferation,adhesion and differentiation.This review is aimed to introduce the structures and functions of integrins and their physiological roles in anoikis.更多还原