【摘要】 随着化疗药物在肿瘤及自身免疫性疾病的广泛应用,由其导致的卵巢早衰是临床亟待解决的问题。许多研究认为口服避孕药负反馈降低促性腺激素的合成和分泌,使卵巢处于静止状态,免受细胞毒性药物损伤,同时可上调Bcl-2表达及下调Bax表达,抑制卵泡颗粒细胞及卵母细胞凋亡,通过减少氧自由基产生,保护和改善细胞膜的完整性和流动性,调节卵巢组织细胞功能。探讨口服避孕药保护卵巢功能的作用机制,可对进一步研究及临床应用提供依据。更多还原

【Abstract】 Premature ovarian failure(POF) is an important problem when chemotherapy drugs were used in cancer and autoimmune diseases.Oral contraceptions(OCs) can reduce gonadotropins synthesis and secretion by the negative feedback which make ovary dormant status against the damage of cytotoxic drugs.Meanwhile,OCs can restrain apoptosis of follicle granular cell and oocyte by up-regulating Bcl-2 expression and down regulating Bax expression.The integrity and liquidity of cell membrane can be protected by reducing the oxygen free radicals production.This article reviewed the mechanism of oral contraceptives protecting ovarian function.更多还原