【摘要】 目的:探讨超分割放射治疗鼻咽癌对视神经功能的影响。方法:98例鼻咽癌患者随机分入超分割放疗组(研究组)和常规放疗组(对照组),全部患者于放疗前后予视力视野及电生理学检查。结果:两组患者放疗后均可出现放射性视神经损伤,研究组和对照组放疗后第24个月参照RTOG标准视神经损伤发病率分别为5.0%和23.8%,视觉诱发电位检查潜伏期异常发生率分别为15.0%和35.7%,两组间放射性视神经损伤发生率及损伤程度均存在明显差异。结论:超分割放疗能明确减低放射性视神经损伤的发病率及严重程度,改善患者的生活质量。更多还原

【Abstract】 Objective:To investigate the effect of targeting radiotherapy of nasopharyngeal carcinoma(NPC) on the optic neuropathy after radiation therapy.Methods:98 NPC patients were randomly assigned to the hyperfractionated radiotherapy(the experimental group) and conventional fractionation radiotherapy(the control group).All patients received the ophthalmologic evaluation and VEP tests before and after radiation therapy.Results:Of the all patients in the study,12 developed the optic neuropathy.The experimental group,2(5.0%) developed the optic neuropathy compared to 10(23.8%) in the control group.The experimental group had a lower incidence rate of the latency of VEP than the control group(15.0%VS 35.7%).The data showed a decrease in the occurrence of optic neuropathy after hyperfractionation compared with the conventional fractionation radiotherapy.Conclusion:Hyperfractionated radiotherapy can obviously reduce the incidence rate of optic neuropathy and severity degree,and improve the patients’ quality of lives.更多还原