【摘要】 目的通过检测肝细胞癌患者血清中ECM-1和TIMP-2的表达水平,分析ECM-1和TIMP-2与临床病理参数之间的关系及临床意义。方法应用酶联免疫吸附法测定59例肝癌患者血清ECM-1和TIMP-2水平。结果 59例肝癌患者血清ECM-1和TIMP-2平均水平分别为145.08±22.13 pg/ml、30.77±13.89 ng/ml;两者水平均与肿瘤包膜、TNM分级、血管侵犯、肿瘤结节有关(P<0.005),而ECM-1与肿瘤分化程度有关(P<0.005);ECM-1和TIMP-2水平呈显著负相关(r=-0.469,P=0.000)。结论 ECM-1与TIMP-2的表达可能与肝癌侵袭转移密切相关,可作为患者术后复发与转移的预测指标。更多还原

【Abstract】 Objective To investigate the serum levels of extracellular matrix protein 1(ECM-1),tissue inhibitor of matrix metalloproteinase-2(TIMP-2) in patients with hepatocellular carcinoma(HCC).Methods Serum levels of ECM-1 and TIMP-2 were detected by enzyme-linked immunosorbent assay in 59 patients with HCC.Results The serum ECM-1 and TIMP-9 levels were 145.08±22.13 pg/ml and 30.77±13.89 ng/ml,respectively.And they were significantly associated with tumor capsula,TNM stage,vascular invasion and tumor nodes(P<0.005).Furthermore,ECM-1 levels were associated with tumor differentiation,which also were positively correlated with TIMP-2(r=-0.469,P=0.000).Conclusions Expression of ECM-1 and TIMP-2 may be closely related to the invasion and metastasis of HCC,which can be used as a predictor of recurrence and metastasis for postoperative patients.更多还原