【摘要】 文中以2-甲基-5-硝基三氟甲苯,3-碘-4-甲基苯甲酸,咪唑并[1,2-b]哒嗪为主要原料通过自由基反应,还原反应,酰化反应及sonogashira偶联反应等合成泊那替尼。最终产物及中间体的结构经1H NMR。更多还原

【Abstract】 With 2-methyl-5-nitrobenzotrifluoride 3-iodo-4methyl-benzoicacid,imidazo[1,2-b] pyridazine as main material,ponatinib was synthesized via free radical reaction,reduction,acylation and sonogashira coupling reaction.The structure of final compound and intermediates were confirmed by1H NMR.更多还原