【摘要】 观察DHEA(17aα-D-高炔雌二醇-3-乙酯)联合137Csγ射线辐照对EC109移植小鼠肿瘤的抑制作用及放疗后对荷瘤小鼠造血系统的防护作用。将接种食管癌细胞系EC109的裸鼠按照处理方式的不同分为对照组、单照组、DHEA组和DHEA联合辐照组,给药组连续给药9 d,12 d后分别检测肿瘤抑制率、外周血细胞数、骨髓有核细胞数等指标。结果表明,DHEA组抑瘤率明显高于对照组,DHEA联合辐照组的瘤重分别低于单照组和对照组,具有统计学差异(p<0.01)。DHEA联合辐照组的红细胞、血红蛋白均高于对照组及单照组,差异有统计学意义(p<0.05)。提示DHEA联合γ射线辐照对食管癌移植小鼠肿瘤具有显著的协同抗瘤效果,DHEA对辐照后荷瘤小鼠造血系统具有一定的防护作用。更多还原

【Abstract】 The antitumor effect of 17a-D-homo ethynyclestradiol-3-accetate(DHEA) combined with-rays and protective effect of DHEA on hematopoietic function in tumor-bearing mice was studied in this paper.The EC109-inoculated nude mice were divided into four treatment groups as DHEA,DHEA combined with-rays,-rays only,and control group.The groups with DHEA were continuously delivered drugs for 9 days,and the inhibition rate of tumor,blood count,and nucleated cell in bone marrow were examined 12 days later.The results showed that inhibition rate of tumor in DHEA group increased compared with that of control group;the tumor weight of the irradiated group was lighter than that of DHEA combined with-rays group(p<0.01).In DHEA combined with-rays group,RBC and Hb were significantly increased compared with that in radiation group.DHEA and-rays have synergic effect in inhibiting esophageal cancer growth and DHEA can protect hematopoietic function in radiation-injured mice.更多还原