【摘要】 研究了在乙醇溶液中,氯唑西林钠与与四氯对苯醌发生荷移反应,生成稳定的1∶1络合物,最大吸收波长为426.2nm,线性范围40~600μg/mL,表观摩尔吸光系数ε=3.76×102L.mol-1.cm-1。回收率在98.61%~100.4%范围内,相对标准偏差≤2.14%。该方法简便、快速可用于测定药物制剂中氯唑西林钠的含量,结果满意。更多还原

【Abstract】 A new spectrophotometric method was developed for determination of cloxacillin sodium.It is based on a reaction of charge transfer with p-chloranil in ethanol medium.The composition of complex of cloxacillin sodium with p-chloranil both are 1∶1.The calibration curves are linear in the concentration range of 40-600μg/mL.The complexe maximum absorption is at 426.2nm.The apparent molar absorptivity of complex isε=3.76×102 L.mol-1.cm-1.The recovery is 98.61%-100.4% and the relative standard deviation is≤2.14%.The proposed method has been applied to the determination of cloxacillin sodium for injection and capsules form with satisfactory results.更多还原