【摘要】 建立了同时分离测定化妆品中6种对羟基苯甲酸酯类防腐剂的毛细管胶束电动色谱方法。以未涂层熔融石英毛细管柱(47.5 cm×50μm i.d.,leff=39.5 cm)为分离柱,15 mmol/L Tris-H3PO4(pH 7.0)+10 mmol/L丁二酸二异辛酯磺酸钠(AOT)+体积分数10%乙腈为电泳运行液,10 cm高度差进样,10 s,20kV恒压分离,255 nm波长检测。在质量浓度1.0~200 mg/L范围内,6种组分峰面积与相应质量浓度间均具有良好的线性关系(r≥0.9995)。当信噪比(S/N)为2时,各组分的检出限为1.1~1.7 mg/kg。样品加标回收率为84.2%~122.3%。更多还原

【Abstract】 A micellar electrokinetic capillary chromatographic method was established for simple and simultaneous determination of six parabens most often included in cosmetic products, such as methylparaben( MP),ethylparaben( EP),propylparaben( PP),isopropylparaben( iso-PP),butylparaben( BP) and isobutylparaben( iso-BP). Electrophoretic separation was performed on an uncoated capillary( 47. 5 cm ×50 μm i. d,leff = 39. 5cm) at ambient temperature( 15 ± 1℃) with a mixed 15 mmol/L Tris ﹣ H3PO4 buffer( pH 7. 0) containing 10mmol/L dioctyl sodium sulfosuccinate( AOT) and 10%( V/V) acetonitrile. The other optimum experimental conditions were as follows: siphoning injection of 10 s at 10 cm height difference,applied voltage of 20 kV and detection at 255 nm. The curves of peak response versus concentration for six parabens were linear from 1. 0 to 200mg/L with good correlation coefficients( r≥0. 9995). The detection limits of six parabens were found to be 1. 1 ~1. 7 mg/kg based on the signal-to-noise ratio of 2. The recoveries were between 84. 2% and 122. 3%.更多还原