【摘要】 为研究微生物批式流加发酵生产1,3-丙二醇的动力学模型.采用分阶段描述的方法,考虑细胞内甘油、3羟基丙醛、1,3丙二醇的浓度变化,将整个批式流加发酵过程分成若干个间歇和连续流加的阶段.在连续流加阶段,将流加速度看成是随时间变化的函数,依此改进非线性动力系统,分析系统的性质.最后建立参数辨识模型,利用粒子群算法求解.数值计算结果表明:改进后的模型的平均相对误差比现有文献降低3%~5%.这说明改进后的非线性多阶段动力系统比较适合描述微生物批式流加发酵过程.更多还原

【Abstract】 To study the dynamic model of production of 1,3-propanediol by microbial fed-batch fermentation,using segment description method, the whole fed-batch fermentation is divided into several batch and continuous dilution fermentation stages. In the continuous dilution stage, the dilution rate is a function of time. Then an improved nonlinear dynamic system is given and its characters are discussed. A parameter identification model is presented, and it is solved by particle swarm optimization algorithm. Numerical results show that the average relative error is reduced by 3%~5% and the improved dynamic system can better describe microbial fed-batch fermentation.更多还原