【摘要】 目的:探讨了急性脑梗死(ACI)患者治疗前后血清Hcy、hs-CRP和TGF-β1水平的变化及临床意义。方法:应用免疫化学法、免疫比浊法和放射免疫分析对32例ACI患者进行了治疗前后血清Hcy、hs-CRP和TGF-β1检测,并与35名正常健康人作比较。结果:ACI患者在治疗前血清Hcy、hs-CRP和TGF-β1水平均非常显著地高于正常人组(P<0.01),经治疗1个月后则与正常人组比较无显著性差异(P>0.05)。血清Hcy水平与hs-CRP、TGF-β1水平呈正相关(r=0.6146、0.5784,P<0.01)。结论:检测ACI患者治疗前后血清Hcy、hs-CRP和TGF-β1水平的变化对了解病情、观察预后均具有重要的临床价值。更多还原

【Abstract】 Objective To explore the clinical significance of measurement on the changes of serum Hcy,hs-CRP and TGF-β1 levels after treatment in patients with ACI.Methods Serum Hcy(with immunochemistry),serum hs-CRP(with immunoturbidimetry),serum TGF-β1(with RIA) levels were determined in 32 patients with ACI and 35 normal healthy controls.Results Before treatment,serum Hcy,hs-CRPand TGF-β1 levels in the patients were significantly higher than those in controls(P<0.01).After treatment for 1 month,serum Hcy,hs-CRP and TGF-β1 levels were no significant difference(P>0.05).Serum Hcy level showed positively correlated with hs-CRP,TGF-β1 levels(r=0.6146,0.5784,P<0.01).Conclusion Detection the changes of serum Hcy,hs-CRP and TGF-β1 levels after treatment in patient with ACI might be helpful to monitor efficacy of therapy and prognosis.Therefore,possess important clinical value.更多还原