【摘要】 基于肥大细胞及周围组织液与纤维的特征,建立了三维生物力学模型并进行了模拟计算,计算结果显示:纤维结构对细胞周围的力学环境有着显著的影响,并对肥大细胞有一定的保护作用,尤其与组织液流动方向相垂直的纤维影响效果较明显;数值模拟针灸过程中,肥大细胞周围纤维数量的增多会增大细胞表面的最大流速和最大切应力,从而促进肥大细胞的活化和脱颗粒.模型的研究结果与临床和经络针灸实验的研究结果相一致,有助于从生物力学角度对针刺作用的机理进行分析.更多还原

【Abstract】 According to the characteristics of mast cell,surrounding tissue fluid and fibers,3D models were founded for numerical simulation to the research of the mechanical environment around mast cells.It resulted that the structures of the fibers influence the mechanic environment around the mast cells and protect the mast cells especially in the model with the fibers aligned perpendicular to flow.The different models emulate the acupuncture experiment and validate that the maximum velocity and the maximum shear stress will increase by adding the fibers.The simulation has the identical result with the acupuncture experiment and contributes to the mechanism of the effect of acupuncture from the biomechanical analysis.更多还原