【摘要】 目的评价超声和钼靶X线联合诊断2 cm以内乳腺癌的临床价值。方法检索PubMed、Cochrane图书馆、中国生物医学文献服务系统、中国学术期刊出版总库、万方数据知识服务平台(2003/01/01~2013/04/30),纳入关于超声和钼靶X线联合诊断2 cm以内乳腺癌的文献。按QUADAS法评价纳入研究的质量,用Review Manager 5.2和Meta-DiSc 1.4统计软件计算超声、钼靶X线和联合诊断的合并敏感度(SEN)、合并特异度(SPE)、合并诊断比值比(DOR)和综合受试者工作特征曲线下面积(AUC)。结果纳入9个研究,结果显示:SEN超声为0.75,SEN钼靶为0.66,SEN联合为0.92;SPE超声为0.75,SPE钼靶为0.83,SPE联合为0.82;DOR超声为7.11,DOR钼靶为8.67,DOR联合为60.82;AUC超声为0.7902,AUC钼靶为0.8120,AUC联合为0.9496。结论联合应用超声和钼靶X线可明显提高2 cm以内乳腺癌的诊断准确度。更多还原

【Abstract】 Objective To evaluate the diagnostic value of ultrasonography in combination with mammography for breast cancer within 2 cm. Methods The PubMed, the Cochrane Library, CNKI, CBM and Wanfang databases(2003/01/01-2013/04/30) were searched for studies of the diagnostic value of ultrasonography in combination with mammography for breast cancer within 2cm. The quality of the included studies was evaluated according to QUADAS items. The pooled sensitivity(SEN), pooled specificity(SPE), pooled diagnostic odds ratio(DOR), and area under summary receiver operating characteristic curve(AUC)were calculated using Review Manager 5.2 and Meta- DiSc 1.4 software. Results Nine articles were included in the final analysis. The pooled SEN of ultrasonography, mammography and their combination were 0.75, 0.66, and 0.92, the pooled SPE0.75, 0.83, and 0.82, the pooled DOR 7.11, 8.67, and 60.82, and the AUC 0.7902, 0.8120, and 0.9469, respectively. Conclusion The combination of ultrasonography and mammography can increase the diagnostic accuracy for breast cancer within 2 cm.更多还原