Objective To explore the effects on cell proliferation and invasion as well as molecular basis after suppressing EZH2 expression in endometrial carcinoma cells by using siRNAs.Methods RT-PCR was used to examine the expression of EZH2 in endometrial carcinoma and their paracancerous tissues.SiRNAs targeting to EZH2 were transfected to endometrial carcinoma cells,and MTT,FACS,and boyden assays were utilized to examine cell proliferation,cell cycle change,and cell invasion.Finally,the molecular mechanisms of E...
【基金】
湖南省卫生厅科技基金(B2012-005)
【更新日期】
2013-07-16
【分类号】
R737.33
【正文快照】
子宫内膜癌是发生于子宫内膜的一组上皮性恶性肿瘤,好发于围绝经期和绝经后女性。其是最常见的女性生殖系统肿瘤之一,每年新发病人数接近20万,是第3位导致死亡的常见妇科恶性肿瘤。在我国,子宫内膜癌发病率目前仅次于宫颈癌,居女性生殖系统恶性肿瘤的第2位。EZH2(enhancer of z
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