【摘要】 目的观察血清中可溶性细胞凋亡调节蛋白(sFas)的水平及其动态变化是否参与了急性一氧化碳中毒后迟发性脑病(DEACMP)的发生与发展,探索DEACMP可能的发病机制及加重机制。方法收集40例DEACMP患者,分别在发病急性期、恢复期各取血清3 ml,采用酶联免疫吸附法测定sFas水平;收集同期健康老年人36例,取同等量血清进行同样测定,作为对照组进行比较。结果(1)DEACMP患者发病急性期血中sFas含量与正常组无明显差别(P=0.737);(2)DEACMP患者加重期血中sFas含量与健康对照组比较无明显差别(P=0.137);(3)DEACMP组发病急性期血清中sFas含量与恢复期无明显差别(P=0.059)。结论 sFas似乎未参与DEACMP的发生,对其病情加重及发展也没有明显影响。更多还原

【Abstract】 Objective By explore the role of serum soluble Fas(sFas) in occurrence and progression of delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Methods Enzyme-linked immunosorbent assay(ELISA) was used to detect serum sFas levels in 40 patients with DEACMP in acute stage and convalescent stage,with 36 healthy elderly subjects as the control group.Results Serum sFas levels of the patients with DEACMP in both the acute and convalescent stages showed no significant difference from those in the control group(P=0.737 and 0.137,respectively),nor was any significant difference found between the patients in acute and exacerbation stages(P=0.059).Conclusion Serum sFas is not involved in the occurrence and progression of DEACMP.更多还原