参附对大鼠失血性休克炎症因子的抑制作用

【摘要】 目的探讨参附对大鼠失血性休克后早期炎症反应的抑制作用。方法将30只Wistar大鼠随机分为3组,每组10只,分别为空白对照组(A组)、失血休克模型组(B组)和参附治疗组(C组)。采用ELISA测定血清中IL-1β、IL-6、IL-10和TNF-α的浓度。结果 B组和C组血清IL-1β、IL-6、IL-10和TNF-a明显高于A组(P<0.01);B组和C组大鼠相比较,血清IL-1β、IL-6和TNF-α的含量增加,IL-10的含量降低,差异均有统计学意义(P<0.01)。结论参附可有效降低失血性休克后炎症因子的产生。更多还原

【Abstract】 Objective To investigate the Shenfu inhibition of early inflammatory response after hemorrhagic shock in rats. Methods 30 Wistar rats were randomLy divided into three groups(n=10), the control group (A), hemorrhagic shock model group (B) and Shenfu treatment group (C group). The concentration of IL-1 β, IL-6, IL-10 and TNF-α was tested by ELISA. Results The serum IL-1 β, IL-6, IL-10 and TNF-a of group B and group C was significantly higher than that in group A (P<0.01); Compared to group B and group C, serum IL-1 β, IL-6 and TNF-a content increased and IL-10 content decreased, the differences were statistically significant (P<0.01). Conclusion Shenfu can effectively reduce the production of inflammatory cytokines after hemorrhagic shock.更多还原