地佐辛预处理对下肢缺血再灌注损伤的影响分析

【摘要】 目的初步研究地佐辛预处理对下肢缺血再灌注损伤的影响。方法选择18～60岁行择期膝关节镜手术的患者40例,根据术中止血带的工作时间及是否使用地佐辛预处理随机分为4组（各10例）:地佐辛组group（Ⅰ-D）、空白对照组（Ⅰ-B）、地佐辛组（Ⅱ-D）、空白对组（Ⅱ-B）。分别于开放液路前（T₁）及再灌注后2h（T₂）采集静脉血,离心后取上清检测SOD活力、IL-6含量及蛋白含量（pro）。结果与T₁时刻相比,各组T₂时刻SOD的活力均有显著性降低（P<0.05）,IL-6的含量均有显著性增高（P<0.05）;与空白对照组相比,地佐辛组T₂时刻较T₁时刻SOD活力及IL-6含量的变化值没有显著性差异。结论地佐辛预处理对下肢缺血再灌注损伤暂考虑无显著性影响。更多还原

【Abstract】 Objective Preliminary Study Effects of Dezocine pretreatment in lower limb injury induced by ischemia-reperfusion. Methods Forty 18～60 years old patients who have had elective Arthroscopic knee surgery were randomly divided into four groups according to the work time of tourniquet and whether to use Dezocine during the operation(n=10, each): 75～90 mins Dezocine group (Ⅰ-D), 75～90 mins blank control group (Ⅰ- B), 45～60 mins Dezocine group(Ⅱ-D), 45～60 mins blank control group (Ⅱ-B). Collect venous blood respectively before infusion (T1 ) and 2 hours after reperfusion (T2 ). After centrifugation ,the serum was used to detect SOD activity, IL-6 levels and protein content. Results Compared with T1 time,SOD activity were significantly reduced (P<0.05) and IL-6 levels were significantly increased (P<0.05) at T2 of each group; There were no significant differences (P>0.05) between the Dezocine group and the blank control group in the variation of SOD activity and IL-6 levels. Conclusion The effects of Dezocine pretreatment was not significant in lower limb injury induced by ischemia-reperfusion.更多还原