【摘要】 采用复凝聚法,以明胶和海藻酸钠为基质材料制备了啶虫脒缓释微球,以微球的药物包封率和微球外观作为优化制备工艺条件的参考指标,通过L16(45)正交实验得出微球的最佳制备工艺条件:明胶与海藻酸钠的浓度比为2∶1、复凝聚温度为45℃、复凝聚反应所需时间为80min、CaCl2浓度为0.5mol/L、啶虫脒药量为1.0g。利用体外释放实验测试缓释微球的释放特性,结果表明:合成的明胶/海藻酸钠微球对啶虫脒有良好的缓释作用。更多还原

【Abstract】 A complex coacervation method of the sustained-releasing microspheres containing acetamiprid was developed with gelatin and sodium alginate as base materials.The preparation condition were optimized using L16(45)orthogonal experimental design with the drug encapsulation and the shape of the microspheres as criteria.As a result,the optimum preparation conditions of the microspheres were as follows: the concentration ratio of gelatin to sodium alginate was 2∶1,the tempture of the method was 45 ℃,the complex coacervation time was 80 min,the concentration of CaCl2 was 0.5 mol/L,the dosage of acetamiprid was 1.0 g.The release profiles of acetamiprid from the beads were investigated in-vitro,and the result proved that the gelatin/sodium alginate microspheres had a good drug releasing performances for acetamiprid.更多还原