【摘要】 目的观察磷酸肌酸治疗儿童病毒性心肌炎的临床疗效。方法 2009年10月至2011年10月,142例病毒性心肌炎患儿随机分为两组,观察组70例,采用磷酸肌酸治疗,对照组72例采用果糖二磷酸钠治疗,比较两组患者的临床、心电图疗效及肌酸激酶同工酶(CK-MB)的变化。结果观察组的临床总有效率为87.1%,心电图总有效率为90.0%,均明显高于对照组(χ2=5.666、5.505,P<0.05)。两组治疗后CK-MB水平明显降低,与治疗前比较差异有统计学意义(t=4.068、6.172,P<0.05)。并且,观察组治疗后CK-MB水平明显低于对照组(t=4.451,P<0.05)。观察组治疗后CK-MB恢复正常率为92.9%,明显高于对照组的73.6%,差异有统计学意义(χ2=9.361,P<0.05)。结论磷酸肌酸治疗儿童病毒性心肌炎,能够提高治疗效果,改善心肌功能,是儿童病毒性心肌炎的一种良好治疗方案,值得推广应用。更多还原

【Abstract】 Objective To observe the clinical effect of creatine phosphate in the treatment with viral myocarditis of children.Methods From October 2009to October 2011,142children with viral myocarditis were randomly classified into two groups,which observation group with 70cases was treated with creatine phosphate and control group with 72cases was treated with fructose diphosphate sodium.The clinical effect and the electrocardiogram effect and changes of CK-MB between the two groups were compared.Results The clinical total effective rate in observation group was 87.1%,electrocardiogram total effective rate was 90.0%,both two were significantly higher than those in control group(χ2=5.666、5.505,P<0.05).Compared with pre-treatment,the levels of CK-MB were significantly decreased(t=4.451,P<0.05)in both two groups,the observation group were treated with CK-MB level was significantly lower than the control group(t=4.451,P<0.05).The rate of CK-MB return normal in observation group was 92.9%,significantly higher than that in control group with 73.6%(χ2=9.361,P<0.05).Conclusion Creatine phosphate in the treatment with viral myocarditis of children can enhance clinical effect,improve myocardial function,which is a good treatment program and can be applied in clinic.更多还原