【摘要】 目的探讨替莫唑胺联合放疗应用于行恶性胶质瘤切除手术后患者的治疗效果。方法分析该院2008年1月至2011年6月间收治的52例行恶性胶质瘤切除手术后患者的临床病历资料,观察组26例,替莫唑胺化疗联合精确放疗;对照组26例,单纯采用精确放疗。比较采用两种治疗方法患者的预后情况。结果数据经统计学处理,两组CR、PR、SD、PD的比例比较差异无统计学意义(P>0.05)。两组2、3年生存率、中位复发时间的差异有统计学意义(P<0.05)。两组2级呕吐、白细胞1级减少、白细胞2级减少、2级头痛、癫痫发作、2级智力下降的比例差异无统计学意义(P>0.05)。结论替莫唑胺联合放疗应用于恶性胶质瘤切除手术之后的治疗能够有效提高患者长期的生存率,无严重不良反应,是安全、可行的治疗方法。更多还原

【Abstract】 Objective To investigate effect on temozolomide combined with radiotherapy in treatment of patients after resection of malignant glioma.Methods Analyzed clinical data of 52 patients after resection of malignant glioma of our hospital,from Jan 2009 to Jun 2011.Observation group 26 cases,temozolomide combined with radiotherapy;control group 26 cases,only precision radiotherapy.Compared the prognosis of patients with two treatment methods.Results Data was processed by the statistics,the ratio of cases differences of CR,PR,SD,PD about two groups were not significant(P>0.05).2 years,3-year survival rate,median time to recurrence,the differences about two groups were significant(P<0.05).The ratio of cases differences of level 2 vomit,decrease level 1 in white blood cells,decrease level 2 in white blood cells,level 2 headache,seizures,level 2 mental decline about two groups were not significant(P>0.05).Conclusion Temozolomide combined with radiotherapy in treatment of patients after resection of malignant glioma can effectively improve patients′ long-term survival rate,no serious adverse events,and is a safe and viable treatment.更多还原