【摘要】 帕金森病(Parkinson’s disease,PD)患者由于脑内有过多铁沉积,导致自由基的产生,进而脂质过氧化,直接或间接影响着疾病的发生和发展。使用一些定量检测脑铁的MRI新技术,如磁敏感加权成像(SWI),可以敏感地检测到脑内铁浓度的变化。该文着重就PD患者脑铁异常沉积的MRI表现进行综述。更多还原

【Abstract】 Excessive iron accumulation in the brain has been suggested to be a kind of potent toxin, which can initiate and propagate the production of free radicals. leading to lipid peroxidation in Parkinson disease. MR, especially with the use of T2 or T2* sequences including susceptibility weighted imaging(SWI), is an effective method to detect and measure brain iron. The effect of MR on detecting brain iron and abnormal deposition of iron in the brain with PD was reviewed in this article.更多还原