【摘要】 目的:探讨N末端-脑钠肽前体(NT-proBNP)对不稳定型心绞痛(UAP)的诊断价值。方法:怀疑冠心病的住院患者74例,发病在20h内,除外心肌梗死,经冠脉造影确诊UAP 58例、冠脉阴性16例,分别于症状发作后16-18h、症状缓解96h检测血浆NT-proBNP浓度,并应用受试者工作曲线(ROC)分析NT-proBNP对UAP的诊断价值。结果:UAP组患者症状发作后16-18h、症状缓解96h的NT-proBNP水平均明显高于冠脉阴性组患者,差异具有统计学意义(P<0.01)。UAP组患者症状发作后16-18h的血浆NT-proBNP水平明显高于症状缓解96h,差异具有统计学意义(P<0.01)。ROC分析显示,NT-proBNP水平为92.79pg/ml时诊断UAP的灵敏度和特异度分别为94.8%和81.2%。结论:血浆NT-proBNP水平对诊断不稳定型心绞痛有一定的辅助价值。更多还原

【Abstract】 Objective:To investigate the diagnosis value of N-terminal pro-brain natriuretic peptide(NT-proBNP) for unstable angina pectoris(UAP).Methods:74 suspected coronary heart disease patients were diagnosed UAP(58 cases) and coronary negative(16 cases) by coronary angiography(CAG).The course of all patients was in 20 hours and excepted myocardial infarction.The NT-proBNP concentration in blood plasm was detected respectively 16-18 hours after symptoms onset and 96 hours after remission.The diagnosis value of NT-proBNP for UAP was analyzed with ROC.Results:16-18 hours after symptoms onset and 96 hours after remission,the NT-proBNP concentration in blood plasm of UAP patients were all obviously higher than coronary negative patients(P<0.01).Moreover,the NT-proBNP concentration in blood plasm of UAP patients 16-18 hours after symptoms onset was obviously higher than 96 hours after remission(P<0.01).The diagnosis sensitivity and specificity for UAP was respectively 94.8% and 81.2% when NT-proBNP level was 92.79pg/ml. Conclusions: Plasma NT-proBNP concentration has some supplementary values in diagnosis of UAP.更多还原