【摘要】 目的:评估钙镁合剂和甲钴胺对奥沙利铂引起神经毒性的预防作用。方法:采用随机、安慰剂对照的方法,将接受奥沙利铂+氟尿嘧啶+亚叶酸钙方案化疗的90例大肠癌患者随机分为3组,分别给予钙镁合剂、甲钴胺和生理盐水。利用奥沙利铂专用神经毒性分级和神经症状评分(NSS)观察患者神经毒性发生率及严重程度。结果:单纯化疗组、钙镁合剂组、甲钴胺组急性神经毒性发生率分别为93.1%、66.7%、65.5%,差异有统计学意义(P<0.05)。慢性神经毒性,化疗3周期评价时3组之间有统计学意义(P<0.01)。钙镁合剂和甲钴胺组Ⅰ～Ⅲ度神经毒性均低于单纯化疗组(P<0.01和P<0.05),钙镁合剂组和甲钴胺组差异无统计学意义(P>0.05)。化疗6周期时3组差异有统计学意义(P<0.05),钙镁合剂组神经毒性发生率低于单纯化疗组(P<0.05),但甲钴胺组和单纯化疗组差异无统计学意义(P>0.05)。根据NSS评分,单纯化疗组3周期、6周期时评分均高于其他2组(P<0.01和P<0.05),而钙镁合剂和甲钴胺组差异无统计学意义(P>0.05).结论:钙镁合剂和甲钴胺均能降低奥沙利铂神经毒性的发生率和程度。更多还原

【Abstract】 Objective:To evaluate the effects of calcium-magnesium(Ca/Mg) infusion and mecobalamin on preventing the neurotoxicity induced by oxaliplatin.Methods:Taking the method of random and placebo control,90 patients with colon cancer treated with oxaliplatin+fluorouracil+calcium folinate chemotherapy were randomly divided into three groups which were treated with Ca/Mg infusion,mecobalamin and normal saline,respectively.According to Sanofisyn thelabo and neuropathy symptom score(NSS),the neurotoxicity incidence and severity of all patients were observed.Results:The actue neurotoxicity incidence of normal saline,Ca/Mg infusion and mecobalamin group were 27 cases(93.1%),20 cases(66.7%) and 19 cases(65.5%),respectively,which differences were statistical significance(P<0.05).There were significant difference between the chronic neurotoxicity of three groups after 3 cycles of chemotherapy(P<0.01).TheⅠ-Ⅲ degree neurotoxicity of Ca/Mg infusion and mecobalamin groups were no difference(P>0.05),but which were lower than that of chemotherapy group(P<0.01 to P<0.05).After 6 cycles of chemotherapy,there were significant differences between the incidence of neurotoxicity of three groups(P<0.05),the neurotoxicity of Ca/Mg infusion group was lower than that of chemotherapy group(P<0.05),and the differences of mecobalamin and chemotherapy groups were not statistical significance(P>0.05).The NSS score of chemotherapy group was higher than that of other two groups after 3 and 6 cycles of chemotherapy(P<0.01 and P<0.05),but for other two groups had no differences(P>0.05).Conclusions:Ca/Mg infusion and mecobalamin can decrease the incidence and intensity of neurotoxicity induced by oxaliplatin.更多还原