【摘要】 目的观察益气复脉注射液联合硫酸羟氯喹片治疗干燥综合征的临床疗效。方法将80例患者随机分为3组,A组40例,单纯应用益气复脉注射液治疗(每次2.6g,加入生理盐水250mL中静脉滴注,每日1次);B组20例,单用硫酸羟氯喹片治疗(0.2g,每日2次口服);C组20例,应用益气复脉注射液联合硫酸羟氯喹片治疗(用量、用法分别同A、B组)。3组以15天为1个疗程,比较3组治疗前后在口干眼干症状评分、唾液流率、Schirmer试验、血沉(ESR)、C反应蛋白(CRP)及IgG等疗效。结果 3组患者治疗前实验室指标和临床症状比较,差异无统计学意义(P>0.05);治疗后3组患者口干、唾液流率、Schirmer试验、ESR、CRP及IgG等指标较治疗前均有明显改善(P<0.05),且C组优于A、B组,总有效率C组为85%(17/20),优于A组[80%(32/40)]、B组[75%(15/20)],但差异无统计学意义(χ2分别为0.736、0.695,P>0.05)。结论益气复脉注射液联合硫酸羟氯喹片治疗干燥综合征疗效较单用中药/西药效果更好。更多还原

【Abstract】 Objective To observe the clinical efficacy of Yiqi Fumai Injection (YFI) combined hydroxychloroquine sulfate tablet in the treatment of Sjogren′s syndrome patients. Methods Eighty patients were randomly assigned to three groups. Forty patients in Group A were treated with YFI alone, 2.6 g YFI added in 250 mL normal saline for intravenous dripping, once daily. Twenty patients in Group B took hydroxychloroquine sulfate alone, 0.2 g each time, twice daily. Twenty patients in Group C were treated with YFI and hydroxychloroquine sulfate tablet (with the same dose and dosage as Group A and B). Fifteen days was taken as one course of treatment. The scores for dry mouth and dry eyes, the efficacy on salivary flow rate, Schirmer test, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and IgG, and so on were compared among the three groups before and after treatment. Results There was no significant difference in the laboratory parameters and clinical symptoms among the three groups before treatment. After treatment obvious improvement of the scores for dry mouth, the salivary flow rate, Schirmer test, ESR, CRP, and IgG was shown in all the 3 groups (P<0.05). Besides, the optimal effect was shown in Group C. Its total effective rate was 85% (17/20), better than that of Group A [80% (32/40)] and Group B [75% (15/20)], with no statistical difference (χ2=0.736 and 0.695, P>0.05). Conclusion YFU combined hydroxychloroquine sulfate tablet showed better effects in treating Sjogren′s syndrome patients than using Chinese medicine or Western medicine alone.更多还原